You cannot touch to the skin without activating sensory neurons!
With their nerve’s endings innervating all organs including skin and its different cell layers, sensory neurons are sentinels dedicated to inform brain about skin state and to detect all kind of stimuli coming from the environment (temperature, product application….). In addition to this informative role, sensory neurons are also actives cells in the skin able to interact via molecules with skin cells and thus to impact a large variety of biological phenomenon (ageing, wound healing, inflammation…). Based on the culture of human cells, our in-vitro models allow to evaluate compounds effect on this complex sensory neurons / skin cells crosstalk. Thanks to the development of monolayers cultures in 96 well plates or to the use of more complex systems (co-culture system with reconstructed epidermis, Ibidi plates, micro-fluidic chambers) Neuron Experts is able to go from the first intension screening to the test of finish products. As we are able to design specific studies on different supports we not only bring a proof of efficacy of compounds on the skin-sensory neurons interactions but also support claims with proof of concept and mechanism of action identification.

Fields of applications


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Well-being

Developing ingredients being able to activate well-being signaling pathways in sensory neurons can not only improve the feeling and comfort of people but also counteract deleterious effect of chronic stress.

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Ageing

Among the numerous deleterious effects observed in skin with ageing, skin becomes thinner and the density of innervation decreases. This loss of innervation induces difficulties to properly detect any changes in the skin physiology and on its environment. By reactivating sensory neurons and restoring skin innervation it is possible to counteract ageing deleterious effects.

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Wound healing

In addition to their well-known role in regulating inflammatory process in the skin, sensory neurons are able to accelerate cell migration and have to be activated to induce a proper re-innervation of the scar.

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Peripheral Pain / Neuropathic pain

Neuropathic pain is a chronic pain condition, which is a consequence of peripheral nervous (somatosensory) system damages. Among the most common symptoms associated with neuropathic pain, numbness, tingling, burning, stabbing sensations are reported.

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Inflammation and inflammatory diseases

The dense innervation network of sensory neurons given with their ability to transmit information in both direction in the same time (in direction of the central nervous system and in direction of the skin) allows rapid local and systemic neurogenic modulation of skin immunity.

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Pigmentation

Sensory neurons are able to regulate melanocytes proliferation and dendricity and to induce melanogenesis through the secretion of neurotransmitters.

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Itch

Because sensory neurons are responsible for signal transduction of itch, whatever the cause, to the central nervous system, and participate in the maintenance of chronic itch sensation, they are a major target for itch relief.

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Cooling effects

Some receptors of sensory neurons, TRPM8 receptors, are specialized in detecting cold temperature and cooling agents.

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Sensitive skin

Sensory neurons are the focal point of sensitive skin and targeting nociceptors could help provide a soothing sensation.

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Muscle tonicity

It may be important to modulate muscle tone, whether to increase it (counteracting muscle weakness in neuropathies) or to reduce it (participating in reducing facial wrinkles).

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